Development of a thick and functional human adipose-derived stem cell tissue sheet for myocardial infarction repair in rat hearts.

ABSTRACT:

Background

Heart failure (HF) is a major cause of death worldwide. The most effective treatment for HF is heart transplantation, but its use is limited by the scarcity of donor hearts. Recently, stem cell-based therapy has emerged as a promising approach for treating myocardial infarction. Our research group has been investigating the use of human induced pluripotent stem cell-derived cardiomyocyte patches as a potential therapeutic candidate. We have successfully conducted eight cases of clinical trials and demonstrated the safety and effectiveness of this approach. However, further advancements are necessary to overcome immune rejection and enhance therapeutic efficacy. In this study, we propose a novel and efficient technique for constructing mesenchymal stem cell (MSC) tissue s

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10734106 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature