Platelets as delivery vehicles for targeted enrichment of NO^· to cerebral glioma for magnetic resonance imaging.

ABSTRACT: Using a magnetic resonance imaging (MRI) contrast agent, MRI has made substantial contributions to glioma diagnosis. Metal-free MRI agents, such as the nano free radical nitric oxide (NO^·) micelle, can overcome the inherent toxicity of metal-based agents in certain patient populations. However, the low spatial resolution of nano NO^· micelle in MRI limits its clinical development. In this study, we pretreated platelets (PLTs) and loaded them with nano NO^· micelles to synthesize NO^·@PLT, which can overcome the low contrast and poor in vivo stability of nitroxide-based MRI contrast agents. The PLTs can serve as potential drug carriers for targeting and delivering nano NO^· micelles to gliomas and thus increase the contrast in T1-weighted i

SUBMITTER: Ding Y 

PROVIDER: S-EPMC10734142 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature