Combined effect of adiposity and elevated inflammation on incident type 2 diabetes: a prospective cohort study.

ABSTRACT:

Background

Adiposity and elevated inflammation are two hallmarks of hyperglycemia. However, it is unknown whether clustering of elevated inflammation and adiposity interact act on diabetogenesis and lead to a greater risk for incident type 2 diabetes (T2D).

Methods

Adiposity was indicated by body mass index, waist circumference and ultrasonography-measured fatty liver degrees. Elevated inflammation was indicated as high-sensitivity C-reactive protein levels ≥ 2 mg/L. Time-to-event survival analyses were conducted to investigate the joint effect of adiposity and inflammation on incident T2D on both multiplicative and additive scales.

Results

Among 82,172 non-diabetic participants from a prospective cohort in China, 14,278 T2D occurred over a median follow-up of 11 year

SUBMITTER: Wu D 

PROVIDER: S-EPMC10734163 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature