Neutrophil extracellular trap-induced intermediate monocytes trigger macrophage activation syndrome in adult-onset Still's disease.

ABSTRACT:

Background

Adult-onset Still's disease (AOSD) is a systemic autoinflammatory disease characterized by innate immune system activation, with a high risk for macrophage activation syndrome (MAS). MAS development is associated with monocyte/macrophage activation and cytokine storm. Monocytes consist of three different subsets, classical monocytes (CMs, CD14^brightCD16 -), intermediate monocytes (IMs, CD14^brightCD16 +), and non-classical monocytes (NCMs, CD14^dimCD16 +), each has distinct roles in inflammatory regulation. However, the frequencies and regulatory mechanism of monocyte subsets in AOSD patients have not been identified.

Methods

We performed flow cytometry, RNA sequencing, phagocytosis analysis, and enzyme-linked immunosorbent assay to

SUBMITTER: Jia J 

PROVIDER: S-EPMC10734198 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature