A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2.

ABSTRACT: The mandibular condylar cartilage (MCC) is an essential component of the temporomandibular joint, which orchestrates the vertical growth of the mandibular ramus through endochondral ossification with distinctive modes of cell differentiation. Parathyroid hormone-related protein (PTHrP) is a master regulator of chondrogenesis; in the long bone epiphyseal growth plate, PTHrP expressed by resting zone chondrocytes promotes chondrocyte proliferation in the adjacent layer. However, how PTHrP regulates chondrogenesis in the MCC remains largely unclear. In this study, we used a Pthrp-mCherry knock-in reporter strain to map the localization of PTHrP⁺ cells in the MCC and define the function of PTHrP in the growing mandibular condyle. In the postnatal MCC of Pthrp^mC

SUBMITTER: Tsutsumi-Arai C 

PROVIDER: S-EPMC10734211 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature