Alterations in circulating mitochondrial signals at hospital admission for COPD exacerbation.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) exacerbation (ECOPD) alters the natural course of the disease. To date, only C-reactive protein has been used as a biomarker in ECOPD, but it has important limitations. The mitochondria release peptides (Humanin (HN), FGF-21, GDF-15, MOTS-c and Romo1) under certain metabolic conditions. Here, we aimed to evaluate the pathophysiologic, diagnostic and prognostic value of measuring serum mitochondrial peptides at hospital admission in patients with ECOPD.

Methods

A total of 51 consecutive patients admitted to our hospital for ECOPD were included and followed for 1 year; in addition, 160 participants with stable COPD from our out-patient clinic were recruited as controls.

Results

Serum FGF-21 (p < .001), MOTS-

SUBMITTER: Amado CA 

PROVIDER: S-EPMC10734331 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature