COLEC12 Promotes Tumor Progression and Is Correlated With Poor Prognosis in Gastric Cancer.

ABSTRACT:

Purpose

Collectin subfamily member 12, a transmembrane scavenger receptor C-type lectin, is aberrantly expressed in various cancers. However, its physiological role in gastric cancer remains somewhat unclear. This study aimed to investigate the Collectin subfamily member 12 expression pattern in human gastric cancer and its role in gastric cancer progression.

Methods

The Kaplan-Meier method was used for survival analysis. The univariate and multivariate Cox proportional hazards regression models were used to identify independent predictors for progression-free survival and overall survival. The effects of Collectin subfamily member 12 on gastric cancer cell proliferation, migration, invasion, and apoptosis were detected through the cell counting kit-8 assay, colony formation

SUBMITTER: Sun X 

PROVIDER: S-EPMC10734338 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature