Insights into virulence: structure classification of the Vibrio parahaemolyticus RIMD mobilome.

ABSTRACT:

Importance

The pandemic Vpar strain RIMD causes seafood-borne illness worldwide. Previous comparative genomic studies have revealed pathogenicity islands in RIMD that contribute to the success of the strain in infection. However, not all virulence determinants have been identified, and many of the proteins encoded in known pathogenicity islands are of unknown function. Based on the EOCD database, we used evolution-based classification of structure models for the RIMD proteome to improve our functional understanding of virulence determinants acquired by the pandemic strain. We further identify and classify previously unknown mobile protein domains as well as fast evolving residue positions in structure models that contribute to virulence and adaptation with respect to a pre-p

SUBMITTER: Kinch LN 

PROVIDER: S-EPMC10734457 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature