Amino acid substitutions in norovirus VP1 dictate host dissemination via variations in cellular attachment.

ABSTRACT:

Importance

All viruses initiate infection by utilizing receptors to attach to target host cells. These virus-receptor interactions can therefore dictate viral replication and pathogenesis. Understanding the nature of virus-receptor interactions could also be important for the development of novel therapies. Noroviruses are non-enveloped icosahedral viruses of medical importance. They are a common cause of acute gastroenteritis with no approved vaccine or therapy and are a tractable model for studying fundamental virus biology. In this study, we utilized the murine norovirus model system to show that variation in a single amino acid of the major capsid protein alone can affect viral infectivity through improved attachment to suspension cells. Modulating plasma membrane mobility redu

SUBMITTER: Mills JT 

PROVIDER: S-EPMC10734460 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature