Defining microbial community functions in chronic human infection with metatranscriptomics.

ABSTRACT:

Importance

The microbial diversity in polymicrobial infections (PMIs) allows for community members to establish interactions with one another, which can result in enhanced disease outcomes such as increased antibiotic tolerance and chronicity. Chronic PMIs result in large burdens on health systems, as they affect a significant proportion of the population and are expensive and difficult to treat. However, investigations into physiology of microbial communities in actual human infection sites are lacking. Here, we highlight that the predominant functions in chronic PMIs differ, and anaerobes, often described as bystanders, may be significant in the progression of chronic infections. Determining the community structure and functions in PMIs is a critical step toward understanding the

SUBMITTER: Adekoya AE 

PROVIDER: S-EPMC10734476 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature