Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of <i>Staphylococcus saprophyticus</i>.

ABSTRACT:

Importance

Staphylococcus saprophyticus is the second most common bacteria associated with urinary tract infections (UTIs) in women. The antimicrobial treatment regimen for uncomplicated UTI is normally nitrofurantoin, trimethoprim-sulfamethoxazole (TMP-SMX), or a fluoroquinolone without routine susceptibility testing of S. saprophyticus recovered from urine specimens. However, TMP-SMX-resistant S. saprophyticus has been detected recently in UTI patients, as well as in our cohort. Herein, we investigated the understudied resistance patterns of this pathogenic species by linking genomic antibiotic resistance gene (ARG) content to susceptibility phenotypes. We describe ARG associations with known and novel SCCmec configurations as well as phage elements in

SUBMITTER: Zhang K 

PROVIDER: S-EPMC10734486 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature