Repurposing of the antimalarial agent tafenoquine to combat MRSA.
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ABSTRACT: Importance
This study represents the first investigation into the antimicrobial effect of TAF against S. aureus and its potential mechanisms. Our data highlighted the effects of TAF against MRSA planktonic cells, biofilms, and persister cells, which is conducive to broadening the application of TAF. Through mechanistic studies, we revealed that TAF targets bacterial cell membranes. In addition, the in vivo experiments in mice demonstrated the safety and antimicrobial efficacy of TAF, suggesting that TAF could be a potential antibacterial drug candidate for the treatment of infections caused by multiple drug-resistant S. aureus.
SUBMITTER: She P
PROVIDER: S-EPMC10734505 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
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Repurposing of the antimalarial agent tafenoquine to combat MRSA.
She Pengfei P Yang Yifan Y Li Linhui L Li Yimin Y Liu Shasha S Li Zehao Z Zhou Linying L Wu Yong Y
mSystems 20231204 6
<h4>Importance</h4>This study represents the first investigation into the antimicrobial effect of TAF against <i>S. aureus</i> and its potential mechanisms. Our data highlighted the effects of TAF against MRSA planktonic cells, biofilms, and persister cells, which is conducive to broadening the application of TAF. Through mechanistic studies, we revealed that TAF targets bacterial cell membranes. In addition, the <i>in vivo</i> experiments in mice demonstrated the safety and antimicrobial effica ...[more]
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Project description:Tafenoquine , an anti-malarial agent, exhibited satisfactory antimicrobial efficacy against Staphylococcus aureus and its highly resistant phenotypes of biofilm and persister cells. Proteomic analysis of Staphylococcus aureus after treated with Tafenoquine was used to explore its underlying mechanisms.
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