Quorum-sensing gene regulates hormetic effects induced by sulfonamides in Comamonadaceae.
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ABSTRACT: Importance
Antibiotics can induce dose-dependent hormetic effects on bacterial cell proliferation, i.e., low-dose stimulation and high-dose inhibition. However, the underlying molecular basis has yet to be clarified. Here, we showed that sulfonamides play dual roles as a weapon and signal against Comamonas testosteroni that can modulate cell physiology and phenotype. Subsequently, through investigating the hormesis mechanism, we proposed a comprehensive regulatory pathway for the hormetic effects of Comamonas testosteroni low-level sulfonamides and determined the generality of the observed regulatory model in the Comamonadaceae family. Considering the prevalence of Comamonadaceae in human guts and environmental ecosystems, we provide critical insights into the health and ecological effects of antibiotics.
SUBMITTER: Lin H
PROVIDER: S-EPMC10734536 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Publications
Quorum-sensing gene regulates hormetic effects induced by sulfonamides in Comamonadaceae.
Lin Hui H Ning Xue X Wang Donglin D Wang Qiaojuan Q Bai Yaohui Y Qu Jiuhui J
Applied and environmental microbiology 20231204 12
<h4>Importance</h4>Antibiotics can induce dose-dependent hormetic effects on bacterial cell proliferation, i.e., low-dose stimulation and high-dose inhibition. However, the underlying molecular basis has yet to be clarified. Here, we showed that sulfonamides play dual roles as a weapon and signal against <i>Comamonas testosteroni</i> that can modulate cell physiology and phenotype. Subsequently, through investigating the hormesis mechanism, we proposed a comprehensive regulatory pathway for the ...[more]
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