Formaldehyde induced the cardiac damage by regulating the NO/cGMP signaling pathway and L-Ca²⁺ channels.

ABSTRACT:

Background

Formaldehyde (FA) is a common environmental pollutant that has been found to cause negative cardiovascular effects, however, the toxicological mechanism is not well understood. In this study, we investigated the molecular effects of the Nitric Oxide (NO)/cyclic Guanosine Monophosphate (cGMP) signaling pathway and L-type calcium (L-Ca²⁺) channels in rat hearts.

Methods

We designed the short-term FA exposure on the rat heart in different concentrations (0, 0.5, 3, 18 mg/m³). After 7 days of exposure, the rats were sacrificed and the rat tissues were removed for various experiments.

Results

Our experimental data showed that FA resulted in the upregulation NO and cGMP, especially at 18 mg/m³. Further, when exposed to high concen

SUBMITTER: Bai C 

PROVIDER: S-EPMC10734627 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature