Synthesis, molecular modeling, and biological evaluation of novel imatinib derivatives as anticancer agents.

ABSTRACT: Different derivatives of imatinib were synthesized by a 3-step reaction method. The structures of the new compounds were characterized by spectroscopic methods. For quantitative evaluation of the biological activity of the compounds, MTT assays were performed, where four BCR-ABL negative leukemic cell lines (Jurkat, Reh, Nalm-6 and Molt-4), one BCR-ABL positive cell line (K562), and one non-leukemic cell line (Hek293T) were incubated with various concentrations of the derivatives. Although imatinib was specifically designed for the BCR-ABL protein, our results showed that it was also effective on BCR-ABL negative cell lines except for Reh cell line. Compound 9 showed lowest IC₅₀ values against Nalm-6 cells as 1.639 μM, also the values of Compound 10 for each cell were very close

SUBMITTER: Gunay F 

PROVIDER: S-EPMC10734772 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature