Induction of cerebellar cortical neurogenesis immediately following valproic acid exposure in ferret kits.

ABSTRACT:

Introduction

Valproic acid (VPA) is an anticonvulsant/antiepileptic drug that regulates neurogenesis. Its effects vary depending on the timing of exposure and the types of neural progenitors involved. Neonatal exposure to VPA causes autism spectrum disorder-like behaviors in some mammalian species, including ferrets. Ferrets experience the cerebellar cortical histogenesis during early postnatal period. However, no studies have evaluated the effect of VPA on cerebellar corticohistogenesis. The present study aimed to determine the effects of VPA exposure on the developing cerebellar cortex in ferret kits with a particular focus on the cortical neurogenesis.

Methods

The experimental kits each received an intraperitoneal injection of VPA, 200 μg/g body weight, on postnatal days

SUBMITTER: Kamiya S 

PROVIDER: S-EPMC10734798 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature