OssaNMA: An R package for using information from network meta-analyses to optimize the power and sample allocation of a new two-arm trial.

ABSTRACT: Randomized clinical trials (RCTs) are designed for measuring the effectiveness of the treatments and testing a hypothesis regarding the relative effect between two or more treatments. Trial designers are often interested in maximizing power when the total sample size is fixed or minimizing the required total sample size to reach a pre-specified power. One approach to maximizing power proposed by previous researchers is to leverage prior evidence using meta-analysis (NMA) to inform the sample size determination of a new trial. For example, researchers may be interested in designing a two-arm trial comparing treatments A and B which are already in the existing trial network but do not have any direct comparison. The researchers' intention is to incorporate the result into an existing network

SUBMITTER: Ye F 

PROVIDER: S-EPMC10734972 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature