The p53 protein is a suppressor of Atox1 copper chaperon in tumor cells under genotoxic effects.

ABSTRACT: The p53 protein is crucial for regulating cell survival and apoptosis in response to DNA damage. However, its influence on therapy effectiveness is controversial: when DNA damage is high p53 directs cells toward apoptosis, while under moderate genotoxic stress it saves the cells from death and promote DNA repair. Furthermore, these processes are influenced by the metabolism of transition metals, particularly copper since they serve as cofactors for critical enzymes. The metallochaperone Atox1 is under intensive study in this context because it serves as transcription factor allegedly mediating described effects of copper. Investigating the interaction between p53 and Atox1 could provide insights into tumor cell survival and potential therapeutic applications in oncology. This study explore

SUBMITTER: Tsymbal S 

PROVIDER: S-EPMC10735018 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature