Intolerance upon statin rechallenge: A systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Although statins are often discontinued when myalgia arises, a causal relationship may not always exist. How well-tolerated statins are when rechallenge is blinded and controlled is unclear.

Methods and findings

We performed a systematic review and meta-analysis (PROSPERO CRD42023437648) to evaluate the success of statin rechallenge versus matched placebo in those who were previously statin intolerant. Our primary outcome was intolerance; our secondary outcome was the myalgia or global symptom score. Medline, Embase, CINAHL Plus, Scopus, and CENTRAL were searched from inception to May 1, 2023. Eligible trials were randomized controlled trials with parallel or crossover designs examining statin rechallenge in statin-intolerant adults. Two independent reviewers sele

SUBMITTER: Kraut R 

PROVIDER: S-EPMC10735036 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature