Impact of Ca²⁺ on membrane catalyzed IAPP amyloid formation and IAPP induced vesicle leakage.

ABSTRACT: Human islet amyloid polypeptide (hIAPP, also known as amylin) is a 37 amino acid pancreatic polypeptide hormone that plays a role in regulating glucose levels, but forms pancreatic amyloid in type-2 diabetes. The process of amyloid formation by hIAPP contributes to β-cell death in the disease. Multiple mechanisms of hIAPP induced toxicity of β-cells have been proposed including disruption of cellular membranes. However, the nature of hIAPP membrane interactions and the effect of ions and other molecules on hIAPP membrane interactions are not fully understood. Many studies have used model membranes with a high content of anionic lipids, often POPS, however the concentration of anionic lipids in the β-cell plasma membrane is low. Here we study the concentration dependent effect of Ca^2+<

SUBMITTER: Li MH 

PROVIDER: S-EPMC10735052 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature