The lncRNA <i>Malat1</i> inhibits miR-15/16 to enhance cytotoxic T cell activation and memory cell formation.

ABSTRACT: Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers. Through biochemical analysis of RNA:protein interactions, we uncovered a non-coding RNA circuit regulating activation and differentiation of cytotoxic T cells composed of the long non-coding RNA Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) and the microRNA family miR-15/16. miR-15/16 is a widely and highly expressed tumor suppressor miRNA family important for cell proliferation and survival. miR-15/16 play important roles in T cell responses to viral infection, including the regulation of antigen-specific T cell expansion and memory. Comparative Argonaute-2 high-throughput sequen

SUBMITTER: Wheeler BD 

PROVIDER: S-EPMC10735224 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature