Catalysis and Electron Transfer in De Novo Designed Metalloproteins.

ABSTRACT: One of the hallmark advances in our understanding of metalloprotein function is showcased in our ability to design new, non-native, catalytically active protein scaffolds. This review highlights progress and milestone achievements in the field of de novo metalloprotein design focused on reports from the past decade with special emphasis on de novo designs couched within common subfields of bioinorganic study: heme binding proteins, monometal- and dimetal-containing catalytic sites, and metal-containing electron transfer sites. Within each subfield, we highlight several of what we have identified as significant and important contributions to either our understanding of that subfield or de novo metalloprotein design as a discipline. These reports are placed in context bo

SUBMITTER: Koebke KJ 

PROVIDER: S-EPMC10735231 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature