The neonatal blood spot metabolome in retinoblastoma.

ABSTRACT:

Background

Retinoblastoma is rare but nevertheless the most common pediatric eye cancer that occurs in children under age 5. High-resolution metabolomics (HRM) is a powerful analytical approach to profile metabolic features and pathways or identify metabolite biomarkers. To date, no studies have used pre-diagnosis blood samples from retinoblastoma cases and compared them to healthy controls to elucidate early perturbations in tumor pathways.

Objectives

Here, we report on metabolic profiles of neonatal blood comparing cases later in childhood diagnosed with retinoblastoma and controls.

Methods

We employed untargeted metabolomics analysis using neonatal dried blood spots for 1327 children (474 retinoblastoma cases and 853 healthy controls) born in California from 1983 t

SUBMITTER: Yan Q 

PROVIDER: S-EPMC10735245 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature