GLP1R rs3765467 Polymorphism Is Associated with the Risk of Early Onset Type 2 Diabetes.

ABSTRACT:

Objective

To investigate the relationship between glucagon-like peptide-1 receptor gene polymorphisms and susceptibility to early onset type 2 diabetes.

Methods

Samples from 316 type 2 diabetes patients with early onset type 2 diabetes (n = 137) and late-onset type 2 diabetes (n = 179) and 145 nondiabetic individuals were analyzed. Multiplex PCR combined with resequencing Hi-Reseq technology was used to detect single nucleotide polymorphisms of the glucagon-like peptide-1 receptor gene, and the allele frequency, genotype distribution, and clinical parameters were analyzed between each diabetes subgroup and the control group.

Results

Sixteen single nucleotide polymorphisms were identified in the exonic region of the glucagon-like peptide-1 receptor

SUBMITTER: Fang Y 

PROVIDER: S-EPMC10735718 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature