DNA methylation status of SHATI/NAT8L promoter in the blood of cigarette smokers.

ABSTRACT:

Aims

Cigarette smoking is a preventable risk factor for various diseases such as cancer, ischemic stroke, cardiac stroke, and chronic obstructive pulmonary disease. Smoking cessation is of great importance not only for individual smokers but also for social health. Regarding current cessation therapies, the effectiveness of nicotine replacement is limited, and the cost of varenicline medication is considerable. Thus, a method for screening smokers who are responsive to cessation therapy based on the therapeutic effectiveness is required. Peripheral biomarkers reflecting smoking dependence status are necessary to establish a method for achieving effective cessation therapy.

Methods

Methylation status of smokers' blood DNA was evaluated focusing on SHATI/NAT8L, an addiction-re

SUBMITTER: Izuo N 

PROVIDER: S-EPMC10739067 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature