Rab7B/42 Is Functionally Involved in Protein Degradation on Melanosomes in Keratinocytes.

ABSTRACT: Keratinocytes uptake melanosomes from melanocytes and retain them in the perinuclear region, where they form melanin caps. Although these processes are crucial to protecting nuclear DNA against ultraviolet injury, the molecular basis of melanosome uptake and decomposition in keratinocytes is poorly understood. One of the major reasons for its being poorly understood is the lack of a specific marker protein that can be used to visualize or monitor melanosomes (or melanosome-containing compartments) that have been incorporated into keratinocytes. In this study, we performed a comprehensive localization screening for mammalian Rab family small GTPases (Rab1-45) and succeeded in identifying 11 Rabs that were enriched around melanosomes that had been incorporated into keratinocytes. We also est

SUBMITTER: Marubashi S 

PROVIDER: S-EPMC10739166 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature