The prognostic value of zonal origin in clinically localized prostate cancer: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Correlation between zonal origin of clinically localized prostate cancer (PC) and biochemical recurrence (BCR) after treatment is still controversial.

Methods

We performed a meta-analysis of published articles to investigate the prognostic value of zonal origin in clinically localized PC. Literature was searched from Medline, Embase, Scopus, and Web of Science, from inception to Nov 1st, 2022. The risk of BCR was compared between PC originating from transition zone with peripheral zone. Relative risk (RR) was pooled in a random-effects model. Subgroup analysis and meta-regression were conducted to assess the source of heterogeneity.

Results

16 cohorts and 19,365 patients were included. PC originating from transition zone was associated with a lower risk o

SUBMITTER: Jin S 

PROVIDER: S-EPMC10739310 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature