The flow of axonal information among hippocampal sub-regions 2: patterned stimulation sharpens routing of information transmission.

ABSTRACT: The sub-regions of the hippocampal formation are essential for episodic learning and memory formation, yet the spike dynamics of each region contributing to this function are poorly understood, in part because of a lack of access to the inter-regional communicating axons. Here, we reconstructed hippocampal networks confined to four subcompartments in 2D cultures on a multi-electrode array that monitors individual communicating axons. In our novel device, somal, and axonal activity was measured simultaneously with the ability to ascertain the direction and speed of information transmission. Each sub-region and inter-regional axons had unique power-law spiking dynamics, indicating differences in computational functions, with abundant axonal feedback. After stimulation, spiking, and burst rat

SUBMITTER: Lassers SB 

PROVIDER: S-EPMC10739322 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature