Plasma Levels of mir-34a-5p Correlate with Systemic Inflammation and Low Naive CD4 T Cells in Common Variable Immunodeficiency.

ABSTRACT:

Purpose

Common variable immunodeficiency (CVID) is a primary antibody deficiency that commonly manifests as recurrent infections. Many CVID patients also suffer from immune dysregulation, an inflammatory condition characterized by polyclonal lymphocytic tissue infiltration and associated with increased morbidity and mortality. The genetic cause is unknown in most CVID patients and epigenetic alterations may contribute to the broad range of clinical manifestations. MicroRNAs are small non-coding RNAs that are involved in epigenetic modulation and may contribute to the clinical phenotype in CVID.

Methods

Here, we determined the circulating microRNAome and plasma inflammatory proteins of a cohort of CVID patients with various levels of immune dysregulation and compared them to

SUBMITTER: Nystrom S 

PROVIDER: S-EPMC10739380 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature