Ventricular CSF proteomic profiles and predictors of surgical treatment outcome in chronic hydrocephalus.

ABSTRACT:

Background

By applying an unbiased proteomic approach, we aimed to search for cerebrospinal fluid (CSF) protein biomarkers distinguishing between obstructive and communicating hydrocephalus in order to improve appropriate surgical selection for endoscopic third ventriculostomy vs. shunt implants. Our second study purpose was to look for potential CSF biomarkers distinguishing between patients with adult chronic hydrocephalus benefitting from surgery (responders) vs. those who did not (non-responders).

Methods

Ventricular CSF samples were collected from 62 patients with communicating hydrocephalus and 28 patients with obstructive hydrocephalus. CSF was collected in relation to the patients' surgical treatment. As a control group, CSF was collected from ten patients with unrup

SUBMITTER: Rostgaard N 

PROVIDER: S-EPMC10739511 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature