The NIH pediatric/young adult chordoma clinic and natural history study: Making advances in a very rare tumor.

ABSTRACT:

Background

Chordomas are rare tumors arising from the skull base and spine, with approximately 20 pediatric chordoma cases in the Unitedn States per year. The natural history and optimal treatment of pediatric chordomas, especially poorly differentiated and dedifferentiated subtypes, is incompletely understood. Herein, we present findings from our first National Cancer Institute (NCI) chordoma clinic and a retrospective analysis of published cases of pediatric poorly differentiated chordomas (PDC) and dedifferentiated chordomas (DC).

Methods

Patients less than 40 years old with chordoma were enrolled on the NCI Natural History and Biospecimens Acquisitions Study for Children and Adults with Rare Solid Tumors protocol (NCT03739827). Chordoma experts reviewed patient records,

SUBMITTER: John L 

PROVIDER: S-EPMC10739575 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature