CS-iCCA, A New Clinically Based Staging System for Intrahepatic Cholangiocarcinoma: Establishment and External Validation.

ABSTRACT:

Introduction

Intrahepatic cholangiocarcinoma (iCCA) is a primary liver malignancy with poor prognosis. Current prognostic methods are most accurate for patients with surgically resectable disease. However, a significant proportion of patients with iCCA are not surgical candidates. We aimed to develop a generalizable staging system based on clinical variables to determine prognosis of all patients with iCCA.

Methods

The derivation cohort included 436 patients with iCCA seen between 2000 and 2011. For external validation, 249 patients with iCCA seen from 2000 to 2014 were enrolled. Survival analysis was performed to identify prognostic predictors. All-cause mortality was the primary end point.

Results

Eastern Cooperative Oncology Group status, tumor number, tumor size,

SUBMITTER: Lozada ME 

PROVIDER: S-EPMC10739641 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature