Redox-enabled electronic interrogation and feedback control of hierarchical and networked biological systems.

ABSTRACT: Microelectronic devices can directly communicate with biology, as electronic information can be transmitted via redox reactions within biological systems. By engineering biology's native redox networks, we enable electronic interrogation and control of biological systems at several hierarchical levels: proteins, cells, and cell consortia. First, electro-biofabrication facilitates on-device biological component assembly. Then, electrode-actuated redox data transmission and redox-linked synthetic biology allows programming of enzyme activity and closed-loop electrogenetic control of cellular function. Specifically, horseradish peroxidase is assembled onto interdigitated electrodes where electrode-generated hydrogen peroxide controls its activity. E. coli's stress response regulon, oxyRS, is

SUBMITTER: Wang S 

PROVIDER: S-EPMC10739708 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature