Identification of differences in CD4⁺ T-cell gene expression between people with asthma and healthy controls.

ABSTRACT: Functional enrichment analysis of genome-wide association study (GWAS)-summary statistics has suggested that CD4⁺ T-cells play an important role in asthma pathogenesis. Despite this, CD4⁺ T-cells are under-represented in asthma transcriptome studies. To fill the gap, 3'-RNA-Seq was used to generate gene expression data on CD4⁺ T-cells (isolated within 2 h from collection) from peripheral blood from participants with well-controlled asthma (n = 32) and healthy controls (n = 11). Weighted Gene Co-expression Network Analysis (WGCNA) was used to identify sets of co-expressed genes (modules) associated with the asthma phenotype. We identified three modules associated with asthma, which are strongly enriched for GWAS-identified asthma genes, antigen processing/pr

SUBMITTER: Tutino M 

PROVIDER: S-EPMC10739740 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature