Hyperactive Natural Killer cells in Rag2 knockout mice inhibit the development of acute myeloid leukemia.

ABSTRACT: Immunotherapy has attracted considerable attention as a therapeutic strategy for cancers including acute myeloid leukemia (AML). In this study, we found that the development of several aggressive subtypes of AML is slower in Rag2^-/- mice despite the lack of B and T lymphocytes, even compared to the immunologically normal C57BL/6 mice. Furthermore, an orally active p53-activating drug shows stronger antileukemia effect on AML in Rag2^-/- mice than C57BL/6 mice. Intriguingly, Natural Killer (NK) cells in Rag2^-/- mice are increased in number, highly express activation markers, and show increased cytotoxicity to leukemia cells in a coculture assay. B2m depletion that triggers missing-self recognition of NK cells impairs the growth of AML cells in vivo. In contra

SUBMITTER: Sugimoto E 

PROVIDER: S-EPMC10739813 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature