Anthelmintic efficacy evaluation and mechanism of N-methylbenzo[d]oxazol-2-amine.

ABSTRACT: Parasitic roundworms cause significant sickness and mortality in animals and humans. In livestock, these nematodes have severe economic impact and result in losses in food production on a global scale. None of the currently available drugs ideally suit all treatment circumstances, and the development of drug-resistant nematode strains has become a challenge to control the infection. There is an urgent need to develop novel anthelmintic compounds. According to our previous report, N-methylbenzo[d]oxazol-2-amine (1) showed anthelmintic activity and lowest cytotoxicity. In this study, in vivo anthelmintic properties were evaluated using Trichinella spiralis infected mice. Toxicity was evaluated using the rats and mode of action using molecular docking and metabolomics approaches. The in vivo

SUBMITTER: Prangthip P 

PROVIDER: S-EPMC10739888 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature