Theta mediated dynamics of human hippocampal-neocortical learning systems in memory formation and retrieval.

ABSTRACT: Episodic memory arises as a function of dynamic interactions between the hippocampus and the neocortex, yet the mechanisms have remained elusive. Here, using human intracranial recordings during a mnemonic discrimination task, we report that 4-5 Hz (theta) power is differentially recruited during discrimination vs. overgeneralization, and its phase supports hippocampal-neocortical when memories are being formed and correctly retrieved. Interactions were largely bidirectional, with small but significant net directional biases; a hippocampus-to-neocortex bias during acquisition of new information that was subsequently correctly discriminated, and a neocortex-to-hippocampus bias during accurate discrimination of new stimuli from similar previously learned stimuli. The 4-5 Hz rhythm may facili

SUBMITTER: Gattas S 

PROVIDER: S-EPMC10739909 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature