Spatiotemporal signaling underlies progressive vascular rarefaction in myocardial infarction.

ABSTRACT: Therapeutic angiogenesis represents a promising avenue to revascularize the ischemic heart. Its limited success is partly due to our poor understanding of the cardiac stroma, specifically mural cells, and their response to ischemic injury. Here, we combine single-cell and positional transcriptomics to assess the behavior of mural cells within the healing heart. In response to myocardial infarction, mural cells adopt an altered state closely associated with the infarct and retain a distinct lineage from fibroblasts. This response is concurrent with vascular rarefaction and reduced vascular coverage by mural cells. Positional transcriptomics reveals that the infarcted heart is governed by regional-dependent and temporally regulated programs. While the remote zone acts as an important source

SUBMITTER: Tung LW 

PROVIDER: S-EPMC10739910 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature