Hypothalamic CRH neurons represent physiological memory of positive and negative experience.

ABSTRACT: Recalling a salient experience provokes specific behaviors and changes in the physiology or internal state. Relatively little is known about how physiological memories are encoded. We examined the neural substrates of physiological memory by probing CRH^PVN neurons of mice, which control the endocrine response to stress. Here we show these cells exhibit contextual memory following exposure to a stimulus with negative or positive valence. Specifically, a negative stimulus invokes a two-factor learning rule that favors an increase in the activity of weak cells during recall. In contrast, the contextual memory of positive valence relies on a one-factor rule to decrease activity of CRH^PVN neurons. Finally, the aversive memory in CRH^PVN neurons outlasts the behav

SUBMITTER: Fuzesi T 

PROVIDER: S-EPMC10739955 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature