Dietary pyrroloquinoline quinone improvement of the antioxidant capacity of laying hens and eggs are linked to the alteration of Nrf2/HO-1 pathway and gut microbiota.

ABSTRACT: Pyrroloquinoline quinone disodium (PQQ·Na₂) has been considered a human food supplement for human health promotion with its antioxidant properties. To determine whether PQQ·Na₂ had similar functions to improve the antioxidant ability of layers and eggs, 180 laying hens were fed with 0 or 0.4 mg/kg PQQ·Na₂ diets. Supplementation with PQQ·Na₂ increased the albumen height, Haugh unit of the eggs. PQQ·Na₂ also led to a higher glutathione peroxidase (GSH-Px) concentration in plasma and a lower malondialdehyde (MDA) content in the liver and egg yolk. Similarly, liver gene and protein expression of nuclear factor erythroid 2-related 2 (Nrf2) and heme oxygenase 1 (HO-1) were up-regulated by PQQ·Na_2. Moreover, PQQ·Na₂ incr

SUBMITTER: Shao D 

PROVIDER: S-EPMC10740097 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature