Bidirectional causal relationship between hypercholesterolemia and ischemic heart disease: a Mendelian randomization study.

ABSTRACT:

Background

Ischemic Heart Disease (IHD) is a leading cause of morbidity and mortality worldwide. Hypercholesterolaemia, a metabolic syndrome distinguished by elevated cholesterol levels, is positively correlated with IHD, yet the precise causal relationship between these two health conditions remains to be clearly defined.

Methods

We conducted a two-sample MR analysis using genetic variants associated with hypercholesterolemia and IHD. Various statistical techniques including MR-Egger, Weighted Median, Inverse Variance Weighted (IVW), Simple Mode, and Weighted Mode were employed. We also performed sensitivity analyses to assess pleiotropy, heterogeneity, and influence of individual SNPs. Furthermore, genetic co-localization analysis was performed to identify shared genes bet

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC10740159 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature