Multifactor assessment of ovarian cancer reveals immunologically interpretable molecular subtypes with distinct prognoses.

ABSTRACT:

Background

Ovarian cancer (OC) is a highly heterogeneous and malignant gynecological cancer, thereby leading to poor clinical outcomes. The study aims to identify and characterize clinically relevant subtypes in OC and develop a diagnostic model that can precisely stratify OC patients, providing more diagnostic clues for OC patients to access focused therapeutic and preventative strategies.

Methods

Gene expression datasets of OC were retrieved from TCGA and GEO databases. To evaluate immune cell infiltration, the ESTIMATE algorithm was applied. A univariate Cox analysis and the two-sided log-rank test were used to screen OC risk factors. We adopted the ConsensusClusterPlus algorithm to determine OC subtypes. Enrichment analysis based on KEGG and GO was performed to determine

SUBMITTER: Guo Y 

PROVIDER: S-EPMC10740166 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature