A bidirectional Mendelian randomization study investigating the causal role between gut microbiota and insomnia.

ABSTRACT:

Background

It has emerged that disturbances of the gut microbiota (GM) are linked to insomnia. However, the causality of the observed associations remains uncertain.

Methods

We conducted a two-sample Mendelian randomization analysis based on genome-wide association study data to explore the possible causal link between GM and insomnia. The GM data were from the MiBioGen consortium, while the summary statistics of insomnia were obtained from the FinnGen consortium R9 release data. Cochran's Q statistics were used to analyze instrumental variable heterogeneity.

Results

According to the inverse variance weighted estimates, the family Ruminococcaceae (odds ratio = 1.494, 95% confidence interval:1.004-2.223, p = 0.047) and the genus Lachnospiraceae (odds ratio = 1.7

SUBMITTER: Yang J 

PROVIDER: S-EPMC10740168 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature