Practical considerations of diffusion-weighted MRS with ultra-strong diffusion gradients.

ABSTRACT:

Introduction

Diffusion-weighted magnetic resonance spectroscopy (DW-MRS) offers improved cellular specificity to microstructure-compared to water-based methods alone-but spatial resolution and SNR is severely reduced and slow-diffusing metabolites necessitate higher b-values to accurately characterize their diffusion properties. Ultra-strong gradients allow access to higher b-values per-unit time, higher SNR for a given b-value, and shorter diffusion times, but introduce additional challenges such as eddy-current artefacts, gradient non-uniformity, and mechanical vibrations.

Methods

In this work, we present initial DW-MRS data acquired on a 3T Siemens Connectom scanner equipped with ultra-strong (300 mT/m) gradients. We explore the practical issues assoc

SUBMITTER: Davies-Jenkins CW 

PROVIDER: S-EPMC10740196 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature