Mutations in PGRN gene associated with the risk of psoriasis in Pakistan: a case control study.

ABSTRACT:

Background

Psoriasis is a chronic, autoimmune, papulosquamous skin disorder, characterized by the formation of drop-like papules and silvery-white plaques surrounded by reddened or inflamed skin, existing predominantly on the scalp, knees and elbows. The characteristic inflammation and hyperproliferation of keratinocytes in psoriasis is regulated by progranulin (PGRN), which suppresses the expression and release of inflammatory cytokines, such as TNF-α.

Methodology

In this study mutation analysis of the PGRN gene was performed by extracting the genomic DNA from blood samples of 171 diagnosed psoriasis patients and controls through standard salting-out method, followed by amplification and sequencing of the targeted region of exon 5-7 of PGRN gene.

Results

Three single

SUBMITTER: Saleem S 

PROVIDER: S-EPMC10740244 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature