Male and Female Mitochondria Respond Differently after Exercising in Acute Hypoxia.

ABSTRACT: The use of hypoxic devices among athletes who train in normobaric hypoxia has become increasingly popular; however, the acute effects on heart and brain metabolism are not yet fully understood. This study aimed to investigate the mitochondrial bioenergetics in trained male and female Wistar rats after acute hypoxia training. The experimental plan included exercising for 30 min on a treadmill in a Plexiglas cage connected to a hypoxic generator set at 12.5% O₂ or in normoxia. After the exercise, the rats were sacrificed, and their mitochondria were isolated from their brains and hearts. The bioenergetics for each complex of the electron transport chain was tested using a Clark-type electrode. The results showed that following hypoxia training, females experienced impaired oxidati

SUBMITTER: Lai Y 

PROVIDER: S-EPMC10740434 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature