Short-Term Exposure to Nitrogen Dioxide Modifies Genetic Predisposition in Blood Lipid and Fasting Plasma Glucose: A Pedigree-Based Study.

ABSTRACT: (1) Background: Previous studies suggest that exposure to nitrogen dioxide (NO₂) has a negative impact on health. But few studies have explored the association between NO₂ and blood lipids or fasting plasma glucose (FPG), as well as gene-air pollution interactions. This study aims to fill this knowledge gap based on a pedigree cohort in southern China. (2) Methods: Employing a pedigree-based design, 1563 individuals from 452 families participated in this study. Serum levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), high-density lipoprotein cholesterol (HDLC), and FPG were measured. We investigated the associations between short-term NO₂ exposure and lipid profiles or FPG using linear mixed regression models.

SUBMITTER: Guo H 

PROVIDER: S-EPMC10740487 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature