Interhospital Spread of bla_VIM-1- and bla_CTX-M-15-Producing K. pneumoniae ST15 on an IncR Plasmid in Southern Spain.

ABSTRACT: In 2014-2015, the main CTX-M-15- and OXA-48-producing clone in our region was ST15. Recently, K. pneumoniae ST15 isolates co-producing VIM-1 and CTX-M-15 were detected in several hospitals. The aim was to study the emergence and acquisition of this carbapenemase. Between 2017 and 2019, four hospitals submitted twenty-nine VIM-1- and CTX-M-15-producing K. pneumoniae ST15 isolates to our laboratory. Seven representatives of each XbaI PFGE pulsotype were sequenced using short- and long-read technologies. RAST, CGE databases, and Pathogenwatch were used for resistance determinants and capsule-type analysis. Plasmid comparison was performed with Easyfig2.1. Phylogenetic analysis included other contemporary ST15 isolates from Spain. The 29 isolates were clustered into seven

SUBMITTER: Perez-Palacios P 

PROVIDER: S-EPMC10740488 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature