A Method to Locally Irradiate Specific Organ in Model Organisms Using a Focused Heavy-Ion Microbeam.

ABSTRACT: The functions of organisms are performed by various tissues composed of different cell types. Localized irradiation with heavy-ion microbeams, which inactivate only a portion of the constituent cells without destroying the physical intercellular connections of the tissue, is a practical approach for elucidating tissue functions. However, conventional collimated microbeams are limited in the shape of the area that can be irradiated. Therefore, using a focused heavy-ion microbeam that generates a highly precise beam spot, we developed a technology to uniformly irradiate specific tissues of an organism with a defined dose, which conventional methods cannot achieve. The performance of the developed paint irradiation technology was evaluated. By irradiating the CR-39 ion track detector, we conf

SUBMITTER: Funayama T 

PROVIDER: S-EPMC10740561 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature