A pyroptosis-related signature in colorectal cancer: exploring its prognostic value and immunological characteristics.

ABSTRACT:

Background

The heterogeneity of colorectal cancer (CRC) is the main cause of the disparity of drug sensitivity and the variability of prognosis. Pyroptosis is closely associated with the development and prognosis of various tumors, including CRC. Dividing CRC into distinct subgroups based on pyroptosis is a worthwhile topic for improving the precision treatment and prognosis prediction of CRC.

Methods

We classified patients into two clusters using the consensus clustering based on the pyroptosis-related genes (PRGs). Next, the prognostic signature was developed with LASSO regression analysis using the screened genes from differentially expressed genes (DEGs) by univariate and multivariate Cox analyses. According to the pyroptosis-related score (PR score) calculated with the

SUBMITTER: Jiang P 

PROVIDER: S-EPMC10740607 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature